So mine Nicehash Ethash for BTC, for the most profits. There is no point in mining Autolykos on Nicehash, unless you just feel like making less money.
Switching back and forth IS an issue, its down time and it also screws up ur average hasrates in the pool.
For my hashrates as of right now its 5$ less a day than Eth. Thats $150 a month.
To each their own i guess.